Dr Jon Mabley

Dr. Jon Mabley is a Principal Lecturer and Student Engagement Champion in the School of Pharmacy & Biomolecular Sciences with research interests that focus on the pathophysiological implications of the complications of diabetes and HIV.

He was awarded his Pharmacology degree from University of Wales, College Cardiff and his D.Phil. in Biochemistry from University of Sussex. He completed his post-doctoral training at the University of Kentucky USA before joining Inotek Pharmaceuticals in Boston USA as a pharmacologist working on developing poly (ADP-ribose) polymerase inhibitors and free radical scavengers. In 2002 he became Director of Pharmacology at Inotek Pharmaceuticals. In 2004 he returned to the UK and joined the 国产探花 where he continued researching the role of poly (ADP-ribose) polymerase in disease.

 More recently his research has focused on diabetes and HIV and how complications of these diseases lead to increased morbidity and mortality in patients.

Jon Mabley1

How I like to teach

I teach on a wide variety of courses including the MPharm degree program here at the 国产探花 while also delivering material to medical students at the 国产探花 & Sussex Medical School. I am the indigestion case leader in the 1st year of the MPharm degree as well as being the Therapeutics module leader in the 3rd year, roles that allow me to have a direct impact on the delivery of teaching material to the students.

In the early years of the degree my teaching underpins the basic concepts of organ function and control, pathologies that can disrupt normal function and the available pharmacological interventions that can correct these problems to improve patient morbidity and mortality. My specialized teaching focuses on providing students an understanding of metabolic pathways and how these are disrupted in diabetes and controlled using pharmacological agents.

My lecture material is developed from first principals coupled with interactive questions and supported by online video lecture material. In addition I run experimental practical sessions in the laboratory setting with students obtaining a hands on experience of concepts covered in traditional lectures. I am passionate about student feedback to ensure that they develop and improve their skill base as they move through the degree delivering specific feedback lectures on aspects of their coursework and laboratory performance. Teaching in the later years revolves around special topics and small group teaching where students are exposed to the latest scientific discoveries in recently published journal articles, and research projects where students work within my research group obtaining novel data in the area of diabetes and HIV medicine.

My research interests

My current research interests revolve around the complications associated with diabetes and long-term drug therapies for HIV and thromboembolic events with the goal to understanding the underlying pathophysiological mechanisms.

My research on the complications of diabetes started in 2000 and I was part of the group that first identified the DNA repair enzyme poly (ADP-ribose) polymerase as a central mediator of diabetic cardiovascular complications. I have continued this work looking at the role of the glucose metabolite methylglyoxal and how dicarbonyl stress may play a key role in diabetic complications not just in the cardiovascular system but also in the hepatic and renal systems.

My other major research area stems from an interest in the complications of long-term antiretroviral therapy used to successfully treat HIV infection. We are particularly interested in the molecular mechanisms involved in increasing the risk of patients on antiretroviral drugs to developing cardiovascular and hepatic complications. We have identified poly (ADP-ribose) polymerase activation as a key mediator of antiretroviral-induced cardiovascular cell damage as well as investigating possible adjuvant therapies that may prove effective in protecting against this cellular damage.

Most recently we have started to develop a research program into the complications associated with direct oral anticoagulant therapies such as Rivaroxaban. We have started to investigate how Rivaroxaban may be causing dizziness and headaches in patients necessitating their therapy discontinuation by examining the direct cardiovascular effects of these drugs. In addition we are also investigating how direct oral anticoagulant drugs may cause drug induced liver injury by directly impairing hepatocyte function. This work may lead to improved patient screening and monitoring to optimize the appropriate therapy for patients

Research activity

Current research projects:

  • Role of dicarbonyl stress in diabetic complications
  • HIV medication complications
  • Direct Oral Anticoagulant (DOAC)-mediated cardiovascular effects

Reserach Centres and groups:

Social media

Contact me

Dr Jon Mabley
Principal Lecturer

Pharmacy and Biomolecular Sciences
Moulsecoomb
国产探花
BN2 4GJ

Telephone: +441273641032

Email: J.G.Mabley@brighton.ac.uk

Biography

My interest in disease pathophysiology and cellular pathway manipulation to treat disease states began at the University of Wales Cardiff college in 1988 where I studied for a B.Sc. (Hons.) in Pharmacology. In 1992 I moved to the University of Sussex to study for my D.Phil. in Biochemistry where I examined the role of cytokines in causing pancreatic ß-cell damage through nitric oxide production.

In 1997 I obtained a post-doctoral position in the Department of Surgery at the University of Kentucky USA where I researched the role of saturated fatty acids in causing endothelial cell dysfunction. In 1998 I joined Inotek Pharmaceuticals Corporation a Boston USA based company as a Pharmacologist (promoted to Director of Pharmacology in 2002) where I was involved in pharmacological profiling of three classes of drug, poly (ADP-ribose) polymerase inhibitors, xanthine oxidase inhibitors, and free radical scavengers in a variety of animal models of disease including colitis, diabetes, arthritis, ARDS, Hemorrhagic shock, myocardial infarction, etc. During this time I was an author on over 60 publications and presented at both national and international meetings.

In 2004 I returned to the UK to take up a position as Senior Lecturer in Pharmacology at the 国产探花. I lecture autonomic and diabetes pharmacology to Pharmacy and Medical undergraduates as well as running laboratory practical classes for those courses. I jointly run a special topic on Oxidative Stress based on my previous and current research activity to allow undergraduates appreciation of the link between cutting edge research on the bench to bedside applications. I am the current Student Engagement Champion in the School of Pharmacy & Biomolecular Sciences.

Research output

PhD students

 
NameThesis
   
Previous PhD students
Sharada Laidlay (2016)

A phytochemical and pharmacological investigation into the cardiovascular activity of Bekah Beras, a plant used as a traditional herbal remedy. (2nd supervisor)
Hild Bergin (2014)

Underlying mechanisms of the cardiovascular complications of the anti retroviral agents abavacir, rilpivirine, and etravirine. (1st Supervisor)
Mary Faltz (2013) Cellular mechanisms underlying the cardiovascular toxicity of the highly active anti-retroviral therapy Atripla: efavirenz, emtricitabine, and tenofovir (1st supervisor)
Sevelanne Gordon (2012) Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants: Novel Immunomodulating Agents (1st supervisor)
Elias Katsoulieris (2009) Oxidative and endoplasmic stress in the kidney (2nd supervisor)